RNA Details
Disease Name
cystic fibrosis
Tissue
pancreas
RNA Symbol
Spink1
RNA ID
RNA Type
mRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
pancreatic expression array; H&E staining etc.
Target
NA
Pathway
NA
PubMed ID
Title
Differential expression of the trypsin inhibitor SPINK3 mRNA and the mouse ortholog of secretory granule protein ZG-16p mRNA in the mouse pancreas after repetitive injury
Year
2004
Function
"Because spink3 may be an important serine protease inhibitor, its up-regulation may reflect an important endogenous cytoprotective mechanism in preventing further injury. The up-regulation of spink3 was specific; The mouse homologue of the zymogen-processing protein zg-16p was also highly expressed in the pancreas but sharply down-regulated early in the course of injury."